HISTORY OF SEDATIVE DRUGS – THEIR EVOLUTION IN MEDICINE

two. Histamine Receptor Antagonism: Some sedatives, like antihistamines, exert their sedative effects by blocking histamine receptors while in the brain, specially H1 receptors. Histamine performs a task in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness.Barbiturates are A further class of sedatives, nevertheless T